HESPERIDEN
Product No. P07407
Also known as hesperetin 7-rhamnoglucoside and hesperetin-7-rutinoside.
The flavonoid hesperidin is a flavanone glycoside comprised of the flavanone hesperitin and the disaccharide rutinose. Hesperidin is a solid substance with low solubility in water. The molecular formula is C28H34O15, and the molecular weight is 610.57 daltons.
Hesperidin is classified as a citrus bioflavonoid, and is the predominant flavonoid in lemons and oranges - sweet oranges (Citrus sinensis) and tangelos are the richest dietary sources of hesperidin.
Bioflavonoids are essential for the absorption and processing of vitamin C. Although not vitamins, bioflavonoids were dubbed ‘vitamin P’ by Dr. Albert Szent-Gyorgyi, a famed Hungarian researcher, who won the Nobel Prize in Medicine for his discovery of vitamin C. It was in the course of isolating vitamin C that he came across bioflavonoids, and first experimented with them with much success on a patient with bleeding gums. The bioflavonoids thus first came into use as primarily as protectors of capillaries, the tiniest blood vessels in the body.
Some symptoms originally thought to be due to vitamin C deficiency, such as bruising due to capillary fragility, were found in early studies to be relieved by crude vitamin C extract but not by purified vitamin C. The bioflavonoids were found to be the essential component in correcting this bruising tendency and improving the permeability and integrity of the capillary lining.
Deficiency has been linked with abnormal capillary leakiness as well as pain in the limbs causing aches, weakness, and night leg cramps. Supplemental hesperidin may relieve these problems, as well as help reduce edema or excess swelling in the legs due to fluid accumulation. Hesperidin, in combination with a flavone glycoside called diosmin, is used in Europe for the treatment of venous insufficiency and haemorrhoids.
Hesperidin is thought to have antioxidant, anti-inflammatory, anti-allergic, hypolipidemic, vasoprotective and anticarcinogenic actions. The possible anti-inflammatory and hypolipidemic actions of hesperidin may be due to the action of the hesperetin contained within it.
Hesperetin appears to interfere with the metabolism of arachidonic acid, as well as with histamine release to reduce inflammation, and it also lowers lipid levels by inhibiting enzymes. There is also evidence that hesperetin inhibits histamine release from mast cells, which would account for the possible anti-allergic activity of hesperidin.
Hesperidin has demonstrated anti-hypertensive and diuretic effects. It has also shown some ability to protect against ischemia-reperfusion tissue damage in animal models. Anti-cancer, anti-mutagenic and immune-modulating effects have all been shown with the use of hesperidin in numerous studies. Cancers investigated in these studies include oesophageal, colon, urinary bladder, and skin cancers. In one study that compared the cancer-inhibiting effects of a number of dietary flavonoids and bioflavonoids, hesperidin, hesperetin and catechin were said to be the most potent.
To find out more about this product use our online quote form or get in touch with one of our sales team.