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ALLANTOIN Product No. P01108

Allantoin is a product of protein metabolism and is present in a wide variety of plants such as maple and wheat germ, and in particular, comfrey root. It is also found in mammals as a crystallisable oxidation product of uric acid, in allantoic and amniotic fluids, and in foetal urine.

Allantoin has been termed a cell proliferant and a counter irritant in various texts, including the Merck Index, and the British Pharmaceutical Codex, as it helps alleviate the irritating effects of certain cosmetic ingredients such as soap and detergents, oils, and acidic or alkaline materials.

Allantoin promotes wound healing, speeds up cell regeneration, and has a keratolytic (skin-softening) effect. It promotes and speeds up the healthy, natural processes of the body, helping the skin to heal itself. The action of allantoin in the treatment of wounds is quite complex - the damaged tissue is first cleansed, and rapid regeneration of tissue follows due to cell proliferation promoted by the allantoin.

Allantoin is well tolerated and provides rapid relief from pain after the initial administration. The field of indications for preparations of this type covers everything from minor everyday injuries and irritation, lacerations, cuts and burns, to stubborn wounds, refractory ulcers, eczema and contact dermatitis of the hands. Of particular advantage is the fact that wound healing proceeds without keloid development. In addition, internal and external haemorrhoids respond well to preparations with allantoin. When used on intact skin, allantoin produces a silky, smooth and healthy appearance.

As yet no findings have been published on toxic side effects, allergic reactions or irritation of treated skin areas. Formulations containing Allantoin are eminently suitable for the care of the very tender skin of infants and small children.

Allantoin exhibits good stability in dry formulations. Hydrous pharmaceutical and cosmetic preparations are sufficiently stable in an acid to neutral environment under normal storage conditions. It has been proven to be a valuable active constituent both in cosmetics and in dermatology, on account of its compatibility with the skin and its regenerating effect. In addition, allantoin is compatible with a large number of drugs used in pharmaceutical and dermatological preparations and cosmetics, so that all types of combinations are possible for preparations with specific uses. Allantoin may therefore also be incorporated without difficulty in specialties already available. The employment of allantoin is economical because the concentrations required are very low at around 0.2 to 0.5%. It makes no difference to the complete effectiveness of the product whether the allantoin is in solution, suspension, or dry, powder form.

As well as skin creams, allantoin is suitable for use for;